Top 5 Weed Killers at Home Depot: Expert Review

Is your yard turning into a jungle of unwanted green invaders? Those pesky weeds can quickly take over your beautiful lawn, and getting rid of them feels like a never-ending battle. When you walk into a big store like Home Depot, the sheer number of weed killer bottles can make your head spin. Should you pick the fast-acting spray, the slow-kill granules, or something that promises to be safe for pets?

Choosing the right product is tough because one size rarely fits all. You worry about harming your grass, your children, or your dog. Paying good money for a product that doesn’t work is frustrating, and using the wrong one can actually damage your lawn more than the weeds themselves. We understand that confusion, and we are here to clear the air.

This guide cuts through the confusion. We will break down the top weed killers available at Home Depot. You will learn what works best for different types of weeds and how to apply them safely and effectively. Get ready to reclaim your yard!

Top Weed Killer Home Depot Recommendations

Bestseller No. 1
Roundup Weed & Grass Killer₄ with Sure Shot Wand, Use in and Around Flower Beds, Trees, and Driveways, 1 gal.
  • Roundup Weed & Grass Killer₄ kills tough weeds and grasses to the root, including dandelion, crabgrass, poison ivy, clover (red & white), spotted spurge, and other broadleaf weeds
  • It is rainproof in as fast as 30 minutes and produces visible results in hours
  • Allows for planting 1 to 30 days after application (see booklet for details)
  • Use in or around flower beds and perennial landscape plants, around trees and shrubs, on patios, walkways, and driveways, gravel, or mulch beds, along fences and foundations, and edging around foundations and retaining walls
  • The Sure Shot Wand extends 2 feet and features a shield to help target the spray on the weeds and protect desirable plants from drift
SaleBestseller No. 2
Roundup Dual Action Weed & Grass Killer Plus 4 Month Preventer Concentrate, 32 fl. oz.
  • Roundup Dual Action Weed & Grass Killer Plus 4 Month Preventer Concentrate kills existing weeds and grass down to the root and prevents new weeds from growing for up to 4 months
  • This weed killer and preventer is rainproof in as fast as 30 minutes, and produces visible results in as fast as 6 hours
  • Apply this herbicide to hardscapes and landscapes - cracks and crevices in driveways, sidewalks, and patios, along fences, in mulched beds or around the base of well-established desirable plants, shrubs, or trees, and on gravel areas
  • All ornamental bedding plants, trees, shrubs, sod, and seed can be planted 4 months after application
  • Add 6 fl. oz. of Roundup Dual Action Concentrate per gallon, mix into tank sprayer, and spray weeds (to prevent new weeds and grasses from growing, you must spray the entire area you want to control, not just the emerged weeds)
SaleBestseller No. 3
Stump-Out Stump & Vine Killer, 8 oz Concentrate with Applicator, Fast Acting Home Tree Stump Removal
  • CONTROL WOODY PLANTS & VINES-Stop undesirable listed woody vines, plants and broadleaf weeds.
  • ALSO USED AS STUMP KILLER-Use undiluted to kill stumps and prevent sprouting.
  • USE AS FOLIAR SPRAY-Can be applied using a hose-end or tank sprayer.
  • FOR OUTDOOR USE-Around homes, cabins, fences & walkways.
  • WORKS QUICKLY-Eliminates weeds within 1-6 weeks.
Bestseller No. 4
Round Up Pro Weed Killer 2.5 Gallon
  • Round Up Pro is used in many situations from agricultural farming to industrial vegetation management; It can also be used around residential homes and commercial businesses to control unwanted weeds; Roundup Pro is also used by many highway right of way (ROW) management companies, cities, counties, and municipal governments
  • Easy to use
  • Non-Selective Herbicide
  • Rainfast in just one hour
SaleBestseller No. 5
Control Solutions Inc. 82004319 Eraser Weed & Grass Killer Concentrate, 1_Gallon, 128 oz
  • Country Of Origin: United States
  • Model Number: 82004319
  • Item Package Dimensions: 10.0" L x 15.25" W x 12.0" H
  • Item Package Weight: 35.0 lb
Bestseller No. 6
Ortho GroundClear Weed and Grass Killer2 Concentrate, Kills Dandelions, Chickweed, Crabgrass, Moss and More in Patios and Landscapes, OMRI Listed, 32 fl. oz.
  • People and pets may enter treated areas after spray has dried
  • This fast-acting weed control product absorbs on contact to produce results in just 15 minutes, and is rainproof in 2 hours (upon drying)
  • This weed and grass killer controls weeds in, on and around walkways and driveways, under trees, and in landscape beds; not for use on lawns or grasses you like
  • Dilute this weed killer concentrate per label directions and apply any time of the year to dry weeds that are small and actively growing
  • This 32 fl. oz. container of Ortho GroundClear Weed & Grass Killer2 Concentrate treats up to 600 sq. ft. sq. ft.
SaleBestseller No. 7
Ortho Dial N Spray Hose-End Sprayer for Liquid Weed and Insect Killer, Fungicide, Fertilizer with 14 Dilution Settings
  • The Ortho Dial N Spray Hose End Sprayer makes it easy to spray liquid concentrates such as weed killers, insect killers, fungicides, and fertilizers by applying the exact amount every time, with no mixing, measuring, or mess
  • 3 spray patterns deliver the precise amount of treatment where needed: 1) broadcast is perfect for large areas, 2) jet reaches high places or tough rinse jobs, and 3) shower is light enough for gentle vegetation and flowers
  • 14 dilution settings automatically mix from 1 tsp to 8 oz per gallon of water
  • The ergonomically designed trigger, extended-grip handle, rotating hose connector and anti-backflow device that prevents product from going back into the water system make applying product simple and efficient
  • The multi-use, hose-end sprayer provides a simple lawn solution without mixing or mess in 3 easy steps
SaleBestseller No. 8
PBI/GORDON Trimec Lawn Weed Killer, one gallon
  • Kills Hard-To-Control Lawn Weeds
  • For Use On Cool-Season Grasses
  • Available In one gallon
  • No Assembly Required

Your Guide to Choosing the Best Weed Killer at Home Depot

Weeds can quickly take over your yard. Finding the right weed killer at Home Depot helps you keep your lawn neat. This guide walks you through what to look for. We make it easy to pick the best product for your needs.

Key Features to Look For

When you shop at Home Depot, several features matter. Think about what you want the product to do. These key features make a big difference in your success.

1. Type of Weed Killer
  • Selective: This type kills only certain weeds, like broadleaf weeds. It usually leaves your grass safe.
  • Non-Selective: This kills almost all plants it touches, including grass. Use this for driveways or patios where you want nothing to grow.
2. Application Method
  • Ready-to-Use (RTU): These bottles are already mixed. You just spray them on. They are fast and easy for small jobs.
  • Concentrate: You mix this with water in a sprayer. It saves money if you have a very large area to treat.
3. Speed of Action

Some products work fast, showing results in hours. Others take several days. Decide if you need quick visual results or if a slower, deeper kill is okay.

Important Materials in Weed Killers

The ingredients determine how the weed killer works. You should know the main active ingredients.

Common Active Ingredients
  • Glyphosate: This is a common non-selective ingredient. It kills the entire plant it touches.
  • 2,4-D, Dicamba, or MCPP: These are often found in selective products. They target broadleaf weeds without harming lawn grass.
Safety and Environmental Factors

Always check the label for safety warnings. Some chemicals need time before pets or children can safely use the area again. Choose products with lower toxicity if you have many pets or small children.

Factors That Improve or Reduce Quality

The quality of your weed killer depends on more than just the name brand. Look closely at the label and reviews.

Factors That Improve Quality
  • Rainfastness: High-quality products stick to the weeds quickly. This means if it rains soon after spraying, the product still works well.
  • Systemic Action: Good systemic killers travel throughout the whole plant, including the roots. This stops the weed from growing back.
Factors That Reduce Quality
  • Weak Concentration: If the active ingredient amount is too low, it might only weaken the weed, not kill it completely.
  • Poor Nozzle Design: For spray products, a bad sprayer can lead to uneven coverage, meaning some weeds get missed.

User Experience and Use Cases

Think about where and how you will use the product. This guides your final choice.

Lawn Care vs. Hardscaping

If you treat your lawn, you must use a selective product. You want to protect your healthy grass. If you treat weeds cracking through sidewalks or gravel driveways, a non-selective product is best. These areas need complete clearance.

Ease of Use

For beginners, ready-to-use sprayers are usually the easiest. They prevent mistakes with mixing ratios. Experienced gardeners might prefer concentrates for cost savings on large properties.

10 Frequently Asked Questions (FAQ) About Home Depot Weed Killers

Q: How quickly should I see results?

A: Some fast-acting sprays show yellowing in just a few hours. Others might take a week to show full effect, especially if roots are deep.

Q: Can I use lawn weed killer right before mowing?

A: No. Wait a few days after applying weed killer before you mow. This gives the product time to soak into the weed.

Q: Will rain wash away the weed killer?

A: Many products list a “rainfast” time, often 1 to 4 hours. If it rains before that time passes, you might need to reapply.

Q: Is there a safe weed killer for vegetable gardens?

A: Yes, but you must be careful. Use products labeled safe for edibles, or use physical removal like hand-pulling near your vegetables.

Q: What is the difference between a pre-emergent and a post-emergent killer?

A: Pre-emergents stop seeds from sprouting. Post-emergents kill weeds that have already grown above the soil.

Q: Can I mix different weed killers together?

A: Generally, you should not mix different chemicals unless the label specifically tells you it is safe to do so. Mixing can be dangerous or cancel out the effectiveness.

Q: How long should I wait to plant new grass seed after using weed killer?

A: This varies by product. Read the label carefully; some require waiting a week, others require waiting several weeks before reseeding.

Q: Does Home Depot sell organic weed killers?

A: Yes, Home Depot stocks options using ingredients like vinegar or iron, which many people consider more organic.

Q: Why are some weed killers more expensive?

A: More expensive products often have stronger, longer-lasting formulas, or they include specialized ingredients that target specific tough weeds.

Q: Should I wear protective gear?

A: Always wear long sleeves, gloves, and eye protection when applying any chemical weed killer. Safety is important.