Best Heartworm Preventative – Top Picks & Guide

Imagine your furry friend, full of energy and joy, suddenly facing a silent, invisible threat. Heartworms, tiny parasites transmitted by mosquitoes, can cause serious damage to your dog’s heart and lungs. It’s a scary thought, and for many pet parents, choosing the right heartworm preventative feels like navigating a maze. You want the best for your dog, but the sheer number of products, different ingredients, and varied administration methods can leave you feeling overwhelmed and unsure.

This is where we come in. We understand the confusion and the desire to protect your beloved companion. This blog post is designed to cut through the noise. We’ll break down what heartworm preventatives are, why they are so crucial, and the key factors to consider when making your choice. By the end, you’ll feel more confident and equipped to select the perfect preventative that fits your dog’s needs and your lifestyle.

Let’s dive in and ensure your dog stays happy, healthy, and heartworm-free!

Top Heartworm Preventative Recommendations

No. 1
HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs up to 25 lbs (Blue Box) 6 Month Supply of Chews (Heartworm Disease Preventive)
  • Vet-recommended heartworm preventive
  • Effectively prevents heartworm disease
  • Also treats and controls roundworms & hookworms
  • From the brand trusted over 2.5 billion times
  • Delicious once a month real-beef chew that dogs love
No. 2
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover, Puppy Dewormer (Praziquantel & Pyrantel Pamoate), 2 Chewables
  • Dewormer for Dogs: PetArmor 7 Way Chewable large dog dewormer treats and controls 7 species of worms: 2 tapeworms, 2 roundworms, and 3 types of hookworms
  • Vet Quality Deworming for Dogs: These vet-quality tablets are safe for puppies 12 weeks or older, and large dogs 25.1 to 200 lbs
  • Dewormer Tablets: PetArmor broad spectrum canine dewormer comes in chewable tablets, making it easy and convenient to give to your dog
  • How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dewormer for puppies is not rejected and the full dose of dewormer is eaten
  • Recommended Use: For best results with PetArmor dog dewormer, read and follow label instructions; if you need to retreat your dog, we recommend consulting with a veterinarian and have them perform a fecal test to rule out other issues or parasites
No. 3
HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs 51-100 lbs (Brown Box) 6 Month Supply of Chews (Heartworm Disease Preventive)
  • Vet-recommended heartworm preventive
  • Effectively prevents heartworm disease
  • Also treats and controls roundworms & hookworms
  • From the brand trusted over 2.5 billion times⁵
  • Delicious once a month real-beef chew that dogs love⁶
No. 4
HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs up to 25 lbs (Blue Box) 1 Month Supply of Chews (Heartworm Disease Preventive)
  • Vet-recommended heartworm preventive
  • Effectively prevents heartworm disease
  • Also treats and controls roundworms & hookworms
  • From the brand trusted over 2.5 billion times
  • Delicious once a month real-beef chew that dogs love
No. 5
TRI-HEART PLUS Chewable Tablet for Dogs, up to 25 lbs (Blue Box), 6 Chewable Tablets, 6-Month Supply
  • Prevents heartworm disease, treats, and controls roundworms and hookworms
  • Kills heartworm larvae before they reach your dog’s heart
  • Enjoy year-round protection for your dog, with monthly treatments
  • Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
  • Safe for dogs with beef allergies
No. 6
Simparica Trio Chewable for Dogs, Liver Flavor, 22.1-44 lbs, 1-Month Supply
  • Don’t Just Protect, Triple Protect: Simparica Trio is a monthly chew that protects against three categories of parasites including heartworms, ticks & fleas, and intestinal worms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
  • Heartworm Protection: One dose provided 100% protection against heartworm disease in studies to support FDA-approval.
  • Kills 6 Types of Ticks & FDA- Approved to Prevent Lyme Infections*: The first combo preventative FDA approved to kill six types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick, and Asian Longhorned Tick.
  • Kills Fleas & Intestinal Worms: Prevents flea infestations because it kills fleas before they lay eggs. Prevents tapeworms because it kills fleas. Treats and controls roundworms and hookworms.
  • Satisfaction Guaranteed: Simparica Trio comes with a 100% satisfaction guarantee
No. 7
TRI-HEART PLUS Chewable Tablet for Dogs, 51-100 lbs (Brown Box), 6 Chewable Tablets, 6-Month Supply
  • Prevents heartworm disease, treats, and controls roundworms and hookworms
  • Kills heartworm larvae before they reach your dog’s heart
  • Enjoy year-round protection for your dog, with monthly treatments
  • Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
  • Safe for dogs with beef allergies
No. 8
NexGard Plus (afoxolaner, moxidectin, and pyrantel) Flea and Tick Protection & Heartworm Preventive for Dogs Soft Beef Flavored Chewables, 33.1-66 lbs. (Purple) 1 Chew (1 Month Supply)
  • Convenient one-and-done monthly dosing for parasite protection for dogs
  • Provides flea and tick protection for dogs
  • Kills adult fleas and 5 species of ticks
  • Effective prevention of heartworm disease
  • Treats and controls 3 species of hookworms and 2 species of roundworms

Choosing the Best Heartworm Preventative for Your Furry Friend

Keeping your dog or cat safe from heartworm is super important. Heartworm disease is a serious illness that mosquitoes spread. Luckily, there are great preventatives that stop it. This guide helps you pick the best one for your pet.

1. Key Features to Look For

When you shop for heartworm preventative, keep these things in mind:

  • Effectiveness: The product must stop heartworms. Look for brands recommended by vets.
  • Ease of Use: Is it a chewable treat, a topical liquid, or an injection? Choose what works best for you and your pet.
  • Broad Spectrum Protection: Some preventatives also protect against other nasty parasites like fleas, ticks, and intestinal worms. This can save you money and hassle.
  • Safety: The preventative should be safe for your pet’s age and weight. Always check the label.
  • Veterinarian Approval: It’s always a good idea to ask your vet for their top recommendations. They know your pet’s health best.

2. Important Ingredients

Heartworm preventatives use different ingredients to fight off the worms. Some common ones are:

  • Ivermectin: This is a very common ingredient that kills heartworm larvae.
  • Milbemycin Oxime: Another effective ingredient that stops heartworm development.
  • Selamectin: This ingredient tackles heartworms and also protects against fleas and other parasites.
  • Moxidectin: A powerful ingredient that can be used in both topical and injectable forms.

Always check the active ingredients on the package. This helps you understand what the product does.

3. What Makes a Heartworm Preventative Better or Worse

Several things can make a preventative stand out or fall short:

  • Quality Ingredients: Products with high-quality, proven ingredients are usually more effective.
  • Formulation: A tasty chewable that your dog loves is better than a topical treatment that they hate.
  • Added Protection: Preventatives that fight multiple parasites are often a better value.
  • Brand Reputation: Trusted brands with good reviews tend to offer reliable products.
  • Side Effects: Some pets might have reactions to certain ingredients. Always monitor your pet after giving them medication. If you see anything unusual, contact your vet.

4. User Experience and Use Cases

How people use and feel about these products matters a lot.

  • Chewables: Many dog owners love chewable tablets. They are easy to give, and most dogs think they are treats. This makes giving the monthly dose simple.
  • Topical Treatments: These are applied to the skin, usually between the shoulder blades. They work well for pets who won’t take pills. However, some pets might get skin irritation.
  • Injectables: Some preventatives come as shots given by a vet. These are convenient for owners who forget monthly doses. They offer protection for a longer period.

The best choice depends on your pet’s personality and your routine. If your dog is a picky eater, a chewable might be a challenge. If your cat hates being handled, a topical might be tricky.


Heartworm Preventative FAQs

Q: What is heartworm disease?

A: Heartworm disease is a dangerous illness caused by a parasite called Dirofilaria immitis. Mosquitoes carry it and bite your pet, spreading the worms. These worms grow in the heart and lungs, causing serious health problems.

Q: How do heartworm preventatives work?

A: They kill the immature heartworm larvae before they can grow into adult worms. This stops the disease from starting.

Q: How often do I need to give heartworm preventative?

A: Most preventatives are given once a month. Some injections last longer, like six months or a year. Always follow the product’s instructions or your vet’s advice.

Q: Do all pets need heartworm preventative?

A: Yes, all dogs and cats, even indoor ones, need heartworm preventative. Mosquitoes can get inside homes.

Q: Can my pet get heartworms if they are on preventative?

A: It’s very rare, but not impossible. Preventatives are highly effective, but no medication is 100% perfect. This is why regular vet check-ups are important.

Q: When should I start giving my puppy or kitten heartworm preventative?

A: Your vet will tell you the right age to start. Usually, it’s around 6 to 8 weeks old.

Q: Do I need a prescription for heartworm preventative?

A: Many heartworm preventatives require a prescription from your veterinarian. This is because your vet needs to make sure the product is right for your pet and that your pet is healthy enough to take it.

Q: What if I miss a dose of heartworm preventative?

A: If you miss a dose, contact your veterinarian right away. They will tell you the best way to get your pet back on schedule and if any extra steps are needed.

Q: Can heartworm preventatives protect against other parasites?

A: Yes, many products offer protection against fleas, ticks, and some intestinal worms. This is called broad-spectrum protection.

Q: Are there any side effects to heartworm preventatives?

A: Most pets tolerate heartworm preventatives well. Some mild side effects can include vomiting, diarrhea, or lethargy. Serious reactions are rare. Always talk to your vet if you have concerns.