Imagine finally beating a tough infection, only to face a new, unwelcome guest: Clostridioides difficile, or C. diff. This bacterial overgrowth can cause serious digestive problems and is often a nasty side effect of antibiotic use. If you or a loved one is dealing with C. diff, you know how frustrating and worrying it can be. Many people turn to probiotics, hoping for a natural way to restore gut balance and fight back.
But here’s the tricky part: not all probiotics are created equal, especially when fighting a specific invader like C. diff. Which strains actually work? How do you pick one that won’t cause more harm than good? The sheer number of choices online can feel overwhelming, leaving you unsure if you are wasting time and money on the wrong product.
This post cuts through the confusion. We will break down exactly what you need to look for in a probiotic to support your recovery from C. diff. You will learn about the most effective strains proven to help and what dosage you should aim for. Keep reading to gain the confidence to choose the best probiotic partner for your healing journey!
Top Probiotic For C Diff Infection Recommendations
- Max Strength General Purpose Probiotic: Our non-refrigerated probiotic is designed to support digestive health & gut health. A great choice for those looking to support a diverse healthy microbiome w/ 60B CFU - Probiotics for Women & Men alike. One Month Supply
- Support Your Gut: Our probiotic contains 10 diverse high-quality probiotic strains and organic prebiotics - synergistically working together to support your gut health. Expertly crafted to support occasional constipation, diarrhea, gas & bloating!
- Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains. We use a shelf-stable bottle, acid-resistant capsules, and 60 Billion Colony forming units (CFU) to achieve this!
- Backed By Science - Our probiotics are crafted based on scientific research. We have partnered with a network of expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
- Safety Assured Standard of Quality: Our 60B probiotic is 3rd-party tested for purity and potency. Each bottle is manufactured with love & care in the USA with strict quality control - using imported and domestic ingredients.
- Dual action support: Florastor probiotic helps strengthen digestive support; probiotics for women and men help flush bad bacteria and allow good bacteria to flourish; helps provide immune support and improve digestion by breaking down carbs and sugars*
- Unique strain: These probiotic supplements contain 250mg of the exclusive probiotic strain Saccharomyces boulardii CNCM I-745 for overall gut health; this effective probiotic supplement strain has over 65 years of use and research*
- Daily probiotics for digestive health: To build digestive health and support immunity, take 2 capsules 1-2 times daily*
- Shelf stable: 3-year shelf life; no refrigeration required; exposure to heat or sunlight may lead to melting or damage to the product
- The probiotics of choice: The number 1 selling probiotic in its class worldwide; Florastor formulas are made with ingredients that are vegetarian, gluten-free, titanium dioxide-free and appropriate for lactose intolerance
- RESTORE BALANCE: LGG helps restore the natural balance in your digestive tract; works naturally with your body to ease diarrhea caused by antibiotic use
- PROVEN EFFECTIVE STRAIN: LGG probiotic is a proven effective and clinically studied probiotic strain that helps your digestive
- EASY TO TAKE: Take 1 capsule per day; for optimal results, continued daily use is suggested for 10 days after completion of antibiotic regimen
- NO REFRIGERATION REQUIRED: Every package of Culturelle Probiotics meets the highest standards for purity and potency when consumed; to preserve the billions of CFUs in your Culturelle Probiotics, store them in a cool, dry place away from sunlight
- SUPPORT DIGESTIVE BALANCE: Taking antibiotics can cause Antibiotic-Associated Diarrhea (ADD); AAD can be extremely bothersome; Culturelle Ultimate Balance contains LGG, which helps with occasional diarrhea
- 𝐒𝐀𝐂𝐂𝐇𝐀𝐑𝐎𝐌𝐘𝐂𝐄𝐒 𝐁𝐎𝐔𝐋𝐀𝐑𝐃𝐈𝐈 𝐏𝐑𝐎𝐁𝐈𝐎𝐓𝐈𝐂: Saccharomyces is a patented & clinically studied strain that has been used for its regulatory effect on the intestinal flora, helping to maintain normal balance in the intestine.
- 𝐍𝐎 𝐅𝐈𝐋𝐋𝐄𝐑𝐒: We strive for optimal health. That's why our Saccharomyces Boulardii probiotics do not contain fillers, excipients, flow agents, or the additive magnesium stearate, which is believed to inhibit nutrient absorption. We don't use questionable ingredients and do our due diligence to find authentic versions/forms of nutrients. Our probiotic capsules are non-GMO and gluten-free.
- 𝐍𝐎 𝐑𝐄𝐅𝐑𝐈𝐆𝐄𝐑𝐀𝐓𝐈𝐎𝐍 𝐍𝐄𝐄𝐃𝐄𝐃: Our patented Saccharomyces strain (CNCM I-3799) is stable at body temperature (98.6°F) for survival in gastric acids. It's also stable at room temperature for 24 months. We use a proprietary process of less-aggressive drying at a controlled temperature and lower vacuum to preserve complete probiotic yeast cells, delaying the Saccharomyces aging process.
- 𝐂𝐀𝐍 𝐁𝐄 𝐔𝐒𝐄𝐃 𝐃𝐀𝐈𝐋𝐘:Pure TheraPro Rx Saccharomyces probiotic capsules deliver a minimum of 10 billion colony-forming units per daily serving (250mg per capsule). These probiotics supplement capsules quickly achieve high concentrations in the GI tract, then clear within 3-5 days after discontinuing use. Take 1 to 2 capsules daily in the morning or as directed by a healthcare provider.
- 𝐀𝐁𝐎𝐔𝐓 𝐔𝐒: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.
- PROBIOTIC 5 BILLION CFU: Supports a healthy balance of intestinal flora*
- USEFUL WHEN TRAVELING*: For occasional diarrhea*
- REFRIGERATION RECOMMENDED: Refrigerate as soon as item is delivered to maintain shelf life through the 2-year best by date listed on bottom of bottle.
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
- Packaged in the USA by a family owned and operated company since 1968
- 2-in-1 Prebiotic + Probiotic: Seed DS-01 Daily Synbiotic is formulated with 24 clinically and scientifically studied probiotic strains and a patented, plant-based prebiotic outer capsule to deliver benefits in and beyond the gut. 53.6 Billion AFU.
- Whole-Body Benefits: In addition to bloating relief and improved regularity, DS-01 is formulated for digestive and whole-body benefits, including gut health, digestive health, gut barrier integrity, immune support, skin health, and hearth health.
- Engineered to Survive: Seed’s patented capsule-in-capsule ViaCap delivery technology protects probiotics through digestion to ensure the full probiotic dose reaches the colon. DS-01 is shelf-stable and no refrigeration is required.
- Getting Started: If it's your first time taking DS-01, or its been more than a week since your last dose, take 1 capsule daily for three days before moving on to 2 capsules daily. You may notice mild gastrointestinal discomfort or changes in digestion. Any discomfort typically resolves in 1-2 weeks.
- Customer Support: DS-01 goes through extensive third party testing for safety and quality. If you have questions about DS-01, or aren't satisfied with your purchase, reach out to us directly and we'd be happy to help.
- 𝐒𝐀𝐂𝐂𝐇𝐀𝐑𝐎𝐌𝐘𝐂𝐄𝐒 𝐁𝐎𝐔𝐋𝐀𝐑𝐃𝐈𝐈 𝐏𝐑𝐎𝐁𝐈𝐎𝐓𝐈𝐂: Saccharomyces is a patented & clinically studied strain that has been used for its regulatory effect on the intestinal flora, helping to maintain normal balance in the intestine.
- 𝐍𝐎 𝐅𝐈𝐋𝐋𝐄𝐑𝐒: We strive for optimal health. That's why our Saccharomyces Boulardii probiotics do not contain fillers, excipients, flow agents, or the additive magnesium stearate, which is believed to inhibit nutrient absorption. We don't use questionable ingredients and do our due diligence to find authentic versions/forms of nutrients. Our probiotic capsules are non-GMO and gluten-free.
- 𝐍𝐎 𝐑𝐄𝐅𝐑𝐈𝐆𝐄𝐑𝐀𝐓𝐈𝐎𝐍 𝐍𝐄𝐄𝐃𝐄𝐃: Our patented Saccharomyces strain (CNCM I-3799) is stable at body temperature (98.6°F) for survival in gastric acids. It's also stable at room temperature for 24 months when stored properly. We use a proprietary process of less-aggressive drying at a controlled temperature and lower vacuum to preserve complete probiotic yeast cells, delaying the Saccharomyces aging process.
- 𝐂𝐀𝐍 𝐁𝐄 𝐔𝐒𝐄𝐃 𝐃𝐀𝐈𝐋𝐘: Pure TheraPro Rx Saccharomyces probiotic capsules deliver a minimum of 10 billion colony-forming units per daily serving (250mg per capsule). These probiotics supplement capsules quickly achieve high concentrations in the GI tract, then clear within 3-5 days after discontinuing use. Take two (2) capsules one to two times daily, or as directed by a healthcare practitioner. If detox symptoms occur, lower the dose to ¼ capsule and slowly increase to the full dose. Can be taken with or without food. Please Note: Capsules may be opened and mixed into water, juice, or apple sauce. Consume immediately after mixing. Do not heat.
- 𝐀𝐁𝐎𝐔𝐓 𝐔𝐒: Pure TheraPro Rx was founded in Denver Colorado to formulate and manufacture the highest quality supplements available on the market today. Purity is our priority, which is why we insist on using patented, clinically studied ingredients, and never utilizing fillers, flow agents, excipients, or ingredients sourced from China. We also never use dairy, gluten, corn, soy, or other common allergens in any of our class-leading, practitioner-recommended formulas.
- Dual action support: Florastor probiotic helps strengthen digestive support; probiotics for women and men help flush bad bacteria and allow good bacteria to flourish; helps provide immune support and improve digestion by breaking down carbs and sugars*
- Unique strain: These probiotic supplements contain 250mg of the exclusive probiotic strain Saccharomyces boulardii CNCM I-745 for overall gut health; this effective probiotic supplement strain has over 65 years of use and research*
- Daily probiotics for digestive health: To build digestive health and support immunity, take 2 capsules 1-2 times daily*
- Shelf stable: 3-year shelf life; no refrigeration required; exposure to heat or sunlight may lead to melting or damage to the product
- The probiotics of choice: The number 1 selling probiotic in its class worldwide; Florastor formulas are made with ingredients that are vegetarian, gluten-free, titanium dioxide-free and appropriate for lactose intolerance
The Essential Buying Guide for Probiotics to Fight C. Diff Infection
Clostridioides difficile (C. diff) infection is a serious gut problem. It often happens after taking antibiotics. Antibiotics kill the bad bacteria, but they also wipe out the good bacteria in your gut. This lets C. diff grow too much. Probiotics can help put good bacteria back. Choosing the right one is very important for recovery.
Key Features to Look For in a C. Diff Probiotic
When you shop for a probiotic to help with C. diff, you need to check a few important things. These features make a big difference in how well the product works.
1. Specific Strains Matter Most
Not all probiotics are the same. For C. diff, you need strains that science shows can help fight this specific infection. Look closely at the label.
- Saccharomyces boulardii: This is a beneficial yeast, not a bacteria. Many studies suggest it works very well to prevent or reduce C. diff recurrence. It is often the top recommendation.
- Lactobacillus rhamnosus GG (LGG): This specific strain also has good research supporting its use alongside standard C. diff treatment.
- Bacillus species: Some spore-forming Bacillus strains (like B. coagulans or B. subtilis) are also helpful because they survive stomach acid easily.
2. High Colony Forming Units (CFUs)
CFUs measure how many live, active microbes are in each dose. You need a strong dose to make a difference against C. diff.
- Aim for products offering at least **10 billion CFUs** per dose, especially during active infection or recovery. Higher is often better in this situation.
3. Delivery System and Survivability
The good bacteria must survive your stomach acid to reach your intestines where C. diff lives. This is crucial.
- Look for capsules with **delayed-release technology** or **enteric coating**. These coatings protect the microbes until they reach the lower gut.
Important Materials and Formulation
The ingredients list tells you what you are actually putting into your body. Quality matters here.
Prebiotics (Food for Probiotics)
Some products include prebiotics (like inulin or FOS). These act as food for the good bacteria you are adding. This helps the new strains grow stronger. However, if your C. diff is very active, introducing too many prebiotics too fast might cause gas or bloating. Start with a probiotic-only formula first, unless advised otherwise by a doctor.
Allergens and Fillers
Check the “Other Ingredients” section carefully. People often have sensitivities.
- Ensure the product is **dairy-free, soy-free, and gluten-free** if you have those allergies.
- Avoid excessive artificial colors, flavors, or unnecessary fillers. Simpler is usually safer when dealing with a sensitive gut.
Factors That Improve or Reduce Quality
The way a probiotic is made and stored directly affects its quality.
Factors That Improve Quality:
- Third-Party Testing: Look for seals indicating the product was tested by an independent lab. This confirms the CFU count listed on the bottle is accurate.
- Refrigeration Requirements: While shelf-stable probiotics are convenient, some high-potency strains perform better when refrigerated. Follow storage instructions exactly.
Factors That Reduce Quality:
- Expired Products: Always check the expiration date. Probiotics lose potency over time.
- Poor Packaging: If the bottle or blister pack is damaged, the microbes might have died due to exposure to moisture or air.
User Experience and Use Cases
How people use these probiotics is important for C. diff recovery.
Use Case 1: During Antibiotic Treatment
Many doctors suggest taking probiotics at least two hours apart from taking your prescribed antibiotics. Antibiotics kill bacteria, so timing prevents the antibiotic from wiping out the probiotic right away. Use the probiotic for the entire duration of the antibiotic course.
Use Case 2: Preventing Recurrence
C. diff often comes back after the initial treatment ends. Continue taking a high-quality probiotic for **several weeks or even months** after you finish your antibiotics. This helps keep the good bacteria population stable and discourages C. diff from returning.
User Comfort
When starting any new probiotic, some people experience temporary gas or bloating. If this happens, reduce the dose slightly and then slowly increase it over a few days. If symptoms are severe, stop use and talk to your healthcare provider.
10 Frequently Asked Questions (FAQ) About Probiotics for C. Diff Infection
Q: Can I take probiotics while I am actively taking antibiotics for C. diff?
A: Yes, you usually can. You must separate the doses, taking the probiotic at least two hours before or after your antibiotic dose. This helps the probiotic survive.
Q: Which probiotic strain is best for C. diff?
A: Saccharomyces boulardii is the strain most often recommended by researchers for C. diff prevention and recurrence.
Q: How long should I take the probiotic after my C. diff treatment is over?
A: Most experts suggest continuing the probiotic for at least four to eight weeks after finishing antibiotics to help your gut fully recover.
Q: Are these probiotics safe for children with C. diff?
A: Some strains are safe, but dosage must be adjusted. Always consult your child’s pediatrician before starting any supplement for C. diff.
Q: Do I need to refrigerate all C. diff probiotics?
A: No. Check the label. Some are shelf-stable, while others require refrigeration to keep the bacteria alive and potent.
Q: Will a general daily probiotic work for C. diff?
A: A general probiotic might help overall gut health, but for active C. diff, you need a targeted formula with proven strains like S. boulardii.
Q: What happens if I take the probiotic too close to my antibiotic?
A: The antibiotic might kill the probiotic bacteria before they can reach your intestines and help your gut. Always space them out.
Q: How do I know if the probiotic is working?
A: If you are taking it during treatment, you should see improvement in diarrhea symptoms as directed by your doctor. If you take it afterward, you should avoid getting C. diff again.
Q: Can I stop taking probiotics if I feel better?
A: It is best not to stop immediately. Stopping too soon might leave your gut vulnerable. Talk to your doctor about a safe tapering schedule.
Q: What is the typical dosage in CFUs for C. diff support?
A: A therapeutic dose usually starts around 10 billion CFUs per day, but your doctor might recommend higher amounts depending on the severity of your infection.